Family

Phosphopantetheine adenylyltransferase (IPR001980)

Short name: PPAT

Overlapping homologous superfamilies

Family relationships

None.

Description

Phosphopantetheine adenylyltransferase (PPAT; EC:2.7.7.3) is an essential enzyme in bacteria, responsible for catalyzing the rate-limiting step in coenzyme A (CoA) biosynthesis: catalysis of the reversible transfer of an adenylyl group from ATP to 4'-phosphopantetheine to give dephospho-CoA (DPCOA) and pyrophosphate in the fourth (and penultimate) step of coenzyme A biosynthesis [PMID: 10480925]. The dinucleotide-binding fold of PPAT is homologous to class I aminoacyl-tRNA synthetases [PMID: 11812124, PMID: 10205156]. CoA has been shown to inhibit PPAT and competes with ATP, PhP, and dPCoA. PPAT is a homohexamer in E. coli [PMID: 10208837, PMID: 17873050].

The enzyme had previously been thought to have a role in lipopolysaccharide biosynthesis [PMID: 2033061].

GO terms

Biological Process

GO:0015937 coenzyme A biosynthetic process

Molecular Function

GO:0004595 pantetheine-phosphate adenylyltransferase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
TIGRFAMs
HAMAP
PRINTS
CDD
PANTHER