Dephospho-CoA kinase (IPR001977)

Short name: Depp_CoAkinase

Overlapping homologous superfamilies

Family relationships



This family contains Dephospho-coenzyme A kinase (DPCK, EC:, which catalyzes the final step in dephosphocoenzyme A (dCoA) biosynthesis, the phosphorylation of the 3'-hydroxyl group of ribose using ATP as a phosphate donor.

The crystal structures of a number of the proteins in this entry have been determined, including the structure of the protein from Haemophilus influenzae to 2.0-A resolution in a comlex with ATP. The protein consists of three domains: the nucleotide-binding domain with a five-stranded parallel beta-sheet, the substrate-binding alpha-helical domain, and the lid domain formed by a pair of alpha-helices; the overall topology of the protein resembles the structures of other nucleotide kinases [PMID: 11886213].

GO terms

Biological Process

GO:0015937 coenzyme A biosynthetic process

Molecular Function

GO:0005524 ATP binding
GO:0004140 dephospho-CoA kinase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PROSITE profiles