Stomatin family (IPR001972)

Short name: Stomatin_fam

Overlapping homologous superfamilies


Family relationships


Stomatin is also known as erythrocyte membrane protein band 7.2b. It is a 31 kDa membrane protein [PMID: 9147127], and was named after the rare human disease: haemolytic anaemia hereditary stomatocytosis. Stomatin is believed to be involved in regulating monovalent cation transport through lipid membranes. Absence of the protein in hereditary stomatocytosis is believed to be the reason for the leakage of Na+ and K+ ions into and from erythrocytes [PMID: 9147127]. Stomatin is also expressed in mechanosensory neurons, where it may interact directly with transduction components, including cation channels [PMID: 15471860].

Stomatin proteins have been identified in various organisms, including Caenorhabditis elegans. There are nine stomatin-like proteins in C. elegans, MEC-2 being the one best characterised [PMID: 21501885]. In mammals, other stomatin family members are stomatin-like proteins SLP1, SLP2 and SLP3, and NPHS2 (podocin), which display selective expression patterns [PMID: 12239636]. Stomatin family members are oligomeric, they mostly localise to membrane domains, and in many cases have been shown to modulate ion channel activity.

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

No terms assigned in this category.

Cellular Component

GO:0016020 membrane

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.