Tetracycline resistance protein TetA/multidrug resistance protein MdtG (IPR001958)

Short name: Tet-R_TetA/multi-R_MdtG

Overlapping homologous superfamilies

Family relationships


The tetracycline resistance protein Tet(A) is a tetracycline efflux protein that functions as a metal-tetracycline/H+ antiporter [PMID: 16000721, PMID: 9548929]. This is an energy-dependent process that decreases the accumulation of the antibiotic in whole cells. Tet(A) is encoded by the transposon Tn10, and is an integral membrane protein with twelve potential transmembrane domains. Site-directed mutagenesis studies have shown that a negative charge at position 66 is essential for tetracycline transport [PMID: 2168416], and that the region that includes the dipeptide plays an important role in metal-tetracycline transport; it perhaps acts as a gate that opens on the charge-charge interaction between Asp66 and the metal-tetracycline.The histidine at position 257 plays an essential role in H+ translocation [PMID: 1848846].

Multidrug resistance protein MdtG is found in enterobacteria and confers resistance to fosfomycin and deoxycholate [PMID: 11566977].

Both TetA and MdtG belong to major facilitator superfamily (MFS), the largest and most diverse superfamily of secondary active transporters [PMID: 22458847].

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0005215 transporter activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.