Family

Histone H4 (IPR001951)

Short name: Histone_H4

Family relationships

None.

Description

Histone H4 is one of the five histones, along with H1/H5, H2A, H2B and H3. Two copies of each of the H2A, H2B, H3, and H4 histones ensemble to form the core of the nucleosome [PMID: 16472024]. The nucleosome forms octameric structure that wraps DNA in a left-handed manner. H3 is a highly conserved protein of 135 amino acid residues [PMID: 8121801, PMID: 2041803]. Histones can undergo several different types of post-translational modifications that affect transcription, DNA repair, DNA replication and chromosomal stability. The sequence of histone H4 has remained almost invariant in more then 2 billion years of evolution [PMID: 8121801, PMID: 6808351, PMID: 3340182].

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0003677 DNA binding

Cellular Component

GO:0000786 nucleosome
GO:0005634 nucleus

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
SMART
PRINTS