Family

Galactose-1-phosphate uridyl transferase, class I (IPR001937)

Short name: GalP_UDPtransf1

Family relationships

None.

Description

Galactose-1-phosphate uridyl transferase EC:2.7.7.12 (GalT) catalyses the transfer of an uridyldiphosphate group on galactose (or glucose) 1-phosphate. During the reaction, the uridyl moiety links to a histidine residue. In the Escherichia coli enzyme, it has been shown [PMID: 2845364] that two histidine residues separated by a single proline residue are essential for enzyme activity.

On the basis of sequence similarities, two apparently unrelated families seem to exist. Class-I enzymes are found in eukaryotes as well as some bacteria such as E. coli or Streptomyces lividans, while class-II enzymes have been found so far only in bacteria such as Bacillus subtilis or Lactobacillus helveticus [PMID: 2066342].

GO terms

Biological Process

GO:0006012 galactose metabolic process

Molecular Function

GO:0008108 UDP-glucose:hexose-1-phosphate uridylyltransferase activity
GO:0008270 zinc ion binding

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
TIGRFAMs
PANTHER
PIRSF