Porin, eukaryotic type (IPR001925)

Short name: Porin_Euk

Overlapping homologous superfamilies

Family relationships


Eukaryotic mitochondrial porins are voltage-dependent anion-selective channels (VDAC) that behave as general diffusion pores for small hydrophilic molecules [PMID: 8031826, PMID: 1384178, PMID: 1689252, PMID: 2442148]. The channel adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mV.

The proteins are composed of between 12 to 16 beta-strands that span the mitochondrial outer membrane. Yeast contains two members of this family (genes POR1 and POR2); vertebrates have at least three members (genes VDAC1, VDAC2 and VDAC3) [PMID: 8812436, PMID: 22020053].

GO terms

Biological Process

GO:0098656 anion transmembrane transport

Molecular Function

GO:0008308 voltage-gated anion channel activity

Cellular Component

GO:0005741 mitochondrial outer membrane

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PROSITE patterns