Homologous Superfamily

Asp/Glu racemase (IPR001920)

Short name: Asp/Glu_race

Description

Aspartate racemase (EC:5.1.1.13) and glutamate racemase (EC:5.1.1.3) are two evolutionary related bacterial enzymes that do not seem to require a cofactor for their activity [PMID: 8385993]. Glutamate racemase catalyses the interconversion of d- and l-glutamic acid and is the source of d-glutamate in most bacterial strains. d-Glutamic acid is an important biosynthetic building block since it is required in the formation of peptidoglycan that protects bacteria from osmotic lysis. Two conserved cysteines are present in the sequence of these enzymes. They are expected to play a role in catalytic activity by acting as bases in proton abstraction from the substrate [PMID: 10194325, PMID: 11371180].

Glutamate racemase forms a dimer and each monomer consists of two alpha/beta fold domains [PMID: 10331867].

GO terms

Biological Process

GO:0008152 metabolic process

Molecular Function

GO:0016855 racemase and epimerase activity, acting on amino acids and derivatives

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
SUPERFAMILY