Family

Thiol-activated cytolysin (IPR001869)

Short name: Thiol_cytolysin

Family relationships

None.

Description

Thiol-activated cytolysins [PMID: 2254290] are toxins produced by a variety of Gram-positive bacteria and are characterised by their ability to lyse cholesterol-containing membranes, their reversible inactivation by oxidation and their capacity to bind to cholesterol. All these proteins contain a single cysteine residue, located in their C-terminal section, which has been shown [PMID: 2888650] to be essential for the binding to cholesterol.

GO terms

Biological Process

GO:0009405 pathogenesis

Molecular Function

GO:0015485 cholesterol binding

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PROSITE patterns
Pfam
PRINTS