Glypican (IPR001863)

Short name: Glypican

Overlapping homologous superfamilies


Family relationships


Glypicans [PMID: 8589707, PMID: 7657705] are a family of heparan sulphate proteoglycans which are anchored to cell membranes by a glycosylphosphatidylinositol (GPI) linkage. Six members (GPC1-6) are known in vertebrates [PMID: 11474185]. The main function of glypicans is to regulate several signaling pathways, including those of Wnts, Hedgehogs, fibroblast growth factors and bone morphogenetic proteins (BMPs) [PMID: 18505598, PMID: 24412155].

Structurally, these proteins consist of three separate domains:

  • A signal sequence;
  • An extracellular domain of about 500 residues that contains 12 conserved cysteines probably involved in disulphide bonds and which also contains the sites of attachment of the heparan sulphate glycosaminoglycan side chains;
  • A C-terminal hydrophobic region which is post-translationally removed after formation of the GPI-anchor.

GO terms

Biological Process

GO:0009966 regulation of signal transduction

Molecular Function

No terms assigned in this category.

Cellular Component

GO:0046658 anchored component of plasma membrane
GO:0005578 proteinaceous extracellular matrix

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.