Conserved Site

Phosphatidylethanolamine-binding, conserved site (IPR001858)

Short name: Phosphatidylethanolamine-bd_CS


This entry groups metazoan phosphatidylethanolamine-binding proteins, carboxypeptidase Y inhibitor from Saccharomyces cerevisiae (Baker's yeast) (P14306), and homologues from plants which function in flower development. The members of this family belong to MEROPS proteinase inhibitor family I51, clan I-.

In metazoa the phosphatidylethanolamine-binding proteins are an around 200 residue and found in a variety of tissues [PMID: 7807553]. They bind hydrophobic ligands, such as phosphatidylethanolamine, but also seems [PMID: 7641877] to bind nucleotides such as GTP and FMN, it has been suggested that they could act in membrane remodelling during growth and maturation.

In plants, the phosphatidylethanolamine-binding protein homologues, include:

In Arabidopsis thaliana (Mouse-ear cress), FT together with LEAFY (LFY), IPR002910, promote flowering and are positively regulated by the transcription factor CONSTANS (CO). Loss of FT causes delay in flowering, whereas over expression of FT results in precocious flowering independent of CO or photoperiod. FT acts in part downstream of CO and mediates signals for flowering in an antagonistic manner with its homologous gene, TERMINAL FLOWER1 (TFL1) [PMID: 10583960].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PROSITE patterns