Pili assembly chaperone, bacterial (IPR001829)

Short name: Pili_assmbl_chaperone_bac

Overlapping homologous superfamilies

Family relationships



Most Gram-negative bacteria possess a supramolecular structure - the pili - on their surface, which mediates attachment to specific receptors. Many interactive subunits are required to assemble pili, but their assembly only takes place after translocation across the cytoplasmic membrane. Periplasmic chaperones assist pili assembly by binding to the subunits, thereby preventing premature aggregation [PMID: 8670884, PMID: 1683764]. Pili chaperones are structurally, and possibly evolutionarily, related to the immunoglobulin superfamily [PMID: 1348692, PMID: 17082819]: they contain two globular domains, with a topology identical to an immunoglobulin fold.

GO terms

Biological Process

GO:0061077 chaperone-mediated protein folding
GO:0043711 pilus organization

Molecular Function

No terms assigned in this category.

Cellular Component

GO:0030288 outer membrane-bounded periplasmic space

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.