Domain

Chemokine interleukin-8-like domain (IPR001811)

Short name: Chemokine_IL8-like_dom

Domain relationships

None.

Description

Many low-molecular weight factors secreted by cells including fibroblasts, macrophages and endothelial cells, in response to a variety of stimuli such as growth factors, interferons, viral transformation and bacterial products, are structurally related [PMID: 1910690, PMID: 2149646, PMID: 2687068]. Most members of this family of proteins seem to have mitogenic, chemotactic or inflammatory activities. These small cytokines are also called intercrines or chemokines. They are cationic proteins of 70 to 100 amino acid residues that share four conserved cysteine residues involved in two disulphide bonds, as shown in the following schematic representation:

                             +------------------------------------+
                             |                                    |
     xxxxxxxxxxxxxxxxxxxxxxCxCxxxxxxxxxxxxxxxxxxxxxxxCxxxxxxxxxxxxCxxxxx
                           |                         |
                           +-------------------------+

'C': conserved cysteine involved in a disulphide bond.

Chemokines can be sorted into main groups based on the spacing of the two amino-terminal cysteines. In the first group (see IPR001089), the two cysteines are separated by a single residue (C-x-C), while in the second group (see IPR000827), they are adjacent (C-C).

GO terms

Biological Process

GO:0006955 immune response

Molecular Function

GO:0008009 chemokine activity

Cellular Component

GO:0005576 extracellular region

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
Pfam
SMART
SUPERFAMILY