Domain

Delta/Serrate/lag-2 (DSL) protein (IPR001774)

Short name: DSL

Domain relationships

None.

Description

Ligands of the Delta/Serrate/lag-2 (DSL) family and their receptors, members of the lin-12/Notch family, mediate cell-cell interactions that specify cell fate in invertebrates and vertebrates. In Caenorhabditis elegans, two DSL genes, lag-2 and apx-1, influence different cell fate decisions during development [PMID: 8575327]. Molecular interaction between Notch and Serrate, another EGF-homologous transmembrane protein containing a region of striking similarity to Delta, has been shown and the same two EGF repeats of Notch may also constitute a Serrate binding domain [PMID: 1657403, PMID: 7716513].

GO terms

Biological Process

GO:0007154 cell communication

Molecular Function

No terms assigned in this category.

Cellular Component

GO:0016020 membrane

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
SMART
Pfam
PROSITE profiles