Family

Carbonic anhydrase (IPR001765)

Short name: Carbonic_anhydrase

Family relationships

Description

Carbonic anhydrases (EC:4.2.1.1) (CA) are zinc metalloenzymes which catalyze the reversible hydration of carbon dioxide. In Escherichia coli, CA (gene cynT) is involved in recycling carbon dioxide formed in the bicarbonate-dependent decomposition of cyanate by cyanase (gene cynS). By this action, it prevents the depletion of cellular bicarbonate [PMID: 1740425]. In photosynthetic bacteria and plant chloroplast, CA is essential to inorganic carbon fixation [PMID: 1584776]. Prokaryotic and plant chloroplast CA are structurally and evolutionary related and form a family distinct from the one which groups the many different forms of eukaryotic CA's (see IPR001148). Hypothetical proteins yadF from Escherichia coli and HI1301 from Haemophilus influenzae also belong to this family.

This family also includes the Bacillus subtilis protein YbcF that does not seem to be able to bind zinc, which all carbonic anhydrases are thought to require.

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0004089 carbonate dehydratase activity
GO:0008270 zinc ion binding

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PANTHER
GENE3D
Pfam
SMART
SUPERFAMILY