Domain

ACT-like domain (IPR001721)

Short name: ACT-like_dom

Domain relationships

None.

Description

The ACT domain is a 90 amino acid long domain, which has been named after three of the allosterically regulated enzymes in which it is found: aspartate kinase, chorismate mutase and TyrA (prephenate dehydrogenase) [PMID: 10222208]. The ACT domain is found in a variety of contexts and is proposed to be a structurally conserved regulatory domain involved in the binding of small ligands, such as amino acids. Most of the proteins in which it is found are involved in amino acid and purine metabolism:

  • aspartokinases
  • chorismate mutases
  • prephenate dehydrogenases (TyrA)
  • prephenate dehydratases
  • homoserine dehydrogenases
  • malate dehydrogenases
  • phosphoglycerate dehydrogenases
  • phenylalanine and tryptophan-4-monooxygenases
  • phosphoribosylformylglycinamidine synthase (PurQ)
  • uridylyl transferase and removing enzyme (GlnD)
  • GTP pyrophosphokinase/phosphohydrolase (SpoT/RelA)
  • tyrosine and phenol metabolism operon regulators (TyrR)
  • several uncharacterised proteins from archaea, bacteria and plants that contain from one to four copies of this domain [PMID: 12481063].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PROSITE profiles
Pfam