PI3K p85/p55 subunit (IPR001720)

Short name: PI3kinase_P85_p55

Family relationships



Class I PI3Ks convert PtdIns(4,5)P2 to the critical second messenger PtdIns(3,4,5)P3. Class IA PI3Ks consist of a p110 catalytic subunit bound to one of five regulatory subunits, including p85, p55, and p50 [PMID: 17371237]. The p85 subunits contain the SH3, RhoGAP, and SH2 domains. They recruit the p110 subunit to the membrane, where p110 phosphorylates inositol lipids [PMID: 20582532]. Vertebrates contain two p85 isoforms, alpha and beta.

This entry also includes p55 (also known as subunit gamma).

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0035014 phosphatidylinositol 3-kinase regulator activity

Cellular Component

GO:0005942 phosphatidylinositol 3-kinase complex

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.