Short name: Adrenomedullin
Overlapping homologous superfamilies
- Calcitonin/adrenomedullin (IPR021116)
- Adrenomedullin (IPR001710)
Adrenomedullin is a hypotensive peptide, first identified in human pheochromocytoma arising from adrenal medulla [PMID: 8387282, PMID: 7690563]. The protein is ~185 amino acids in length, and includes a 21-residue putative N-terminal signal sequence [PMID: 7690563]. The active peptide, which is expressed in adrenal glands, lung, kidney, heart, spleen, duodenum and submandibular glands, is thought to function as a hormone in circulation control.
The adrenomedullin precursor is believed to contain 2 cleavage sites, one of which produces the active adrenomedullin hormone, and the other, a 20-residue peptide (proadrenomedullin N-terminal 20 peptide, or proam-n20) of unknown function [PMID: 7688224].
- PR00801 (ADRENOMEDULN)