Membrane insertase YidC/ALB3/OXA1/COX18 (IPR001708)

Short name: YidC/ALB3/OXA1/COX18

Overlapping homologous superfamilies

Family relationships


This entry includes membrane insertase YidC from bacteria, ALBINO3-like proteins from plants, and mitochondrial membrane insertase OXA1 and cytochrome c oxidase assembly protein COX18 from eukaryotes. They are a group of evolutionarily conserved proteins that function in membrane protein integration and protein complex stabilization. They share a conserved region composed of five transmembrane regions [PMID: 25947384].

YidC is required for the insertion of integral membrane proteins into the membrane. It may also be involved in protein secretion processes [PMID: 29295859].

COX18 is a mitochondrial membrane insertase required for the translocation of the C terminus of cytochrome c oxidase subunit II (MT-CO2/COX2) across the mitochondrial inner membrane. It plays a role in MT-CO2/COX2 maturation following the COX20-mediated stabilization of newly synthesized MT-CO2/COX2 protein and before the action of the metallochaperones SCO1/2 [PMID: 28330871].

OXA1 is a mitochondrial inner membrane insertase that mediates the insertion of both mitochondrion-encoded precursors and nuclear-encoded proteins from the matrix into the inner membrane. It links mitoribosomes with the inner membrane [PMID: 22904327].

Plant ALBINO3-like proteins are required for the insertion of some light harvesting chlorophyll-binding proteins (LHCP) into the chloroplast thylakoid membrane [PMID: 26265777, PMID: 19995738].

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0032977 membrane insertase activity

Cellular Component

GO:0016021 integral component of membrane

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.