F-actin-capping protein subunit beta (IPR001698)

Short name: CAPZB

Overlapping homologous superfamilies

Family relationships



The F-actin capping protein binds in a calcium-independent manner to the fast growing ends of actin filaments (barbed end) and thereby restricts its growth. The F-actin capping protein is a heterodimer composed of two unrelated subunits: alpha and beta. Neither of the subunits shows sequence similarity to other filament-capping proteins [PMID: 2341404].

This entry represents the beta subunit (CAPZB), which is a protein of about 280 amino acid residues whose sequence is well conserved in eukaryotic species [PMID: 2179733]. In Drosophila mutations in the alpha and beta subunits cause actin accumulation and subsequent retinal degeneration [PMID: 16143599]. In humans CAPZB is part of the WASH complex that controls the fission of endosomes [PMID: 19922875].

GO terms

Biological Process

GO:0051016 barbed-end actin filament capping

Molecular Function

No terms assigned in this category.

Cellular Component

GO:0008290 F-actin capping protein complex

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.