GMP synthase, C-terminal (IPR001674)

Short name: GMP_synth_C

Overlapping homologous superfamilies

Domain relationships



The amidotransferase family of enzymes utilises the ammonia derived from the hydrolysis of glutamine for a subsequent chemical reaction catalyzed by the same enzyme. The ammonia intermediate does not dissociate into solution during the chemical transformations [PMID: 10387030]. GMP synthetase is a glutamine amidotransferase from the de novo purine biosynthetic pathway. The C-terminal domain is specific to the GMP synthases EC: In prokaryotes this domain mediates dimerisation. Eukaryotic GMP synthases are monomers. This domain in eukaryotes includes several large insertions that may form globular domains [PMID: 8548458].

GO terms

Biological Process

GO:0006177 GMP biosynthetic process
GO:0006164 purine nucleotide biosynthetic process

Molecular Function

GO:0005524 ATP binding
GO:0003922 GMP synthase (glutamine-hydrolyzing) activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.