Hedgehog protein (IPR001657)

Short name: Hedgehog

Overlapping homologous superfamilies


Family relationships



Hedgehog proteins are a family of secreted signal molecules required for embryonic cell differentiation. They are synthesised as inactive precursors with an N-terminal signalling domain linked to a C-terminal autoprocessing domain. The three-dimensional structure of the autolytic domain of the hedgehog protein of shows similarity with the beta-strand core of intein splicing domains. It has hence been termed the hint (Hedgehog/Intein) domain [PMID: 9489693].

The activated hedgehog protein is involved in segment polarity and cell to cell communication, and plays important roles in both early embryogenesis and metamorphosis [PMID: 8166882, PMID: 1280560, PMID: 1394430, PMID: 1340474]. The protein is expressed in embryo stripes [PMID: 8166882], and in several groups of cells belonging to the foregut, hindgut and various other unidentified tissues. Maximum expression is seen in embryos 6-12 hours after fertilisation, and in pupae 1-24 hours after puparium formation.

GO terms

Biological Process

GO:0007267 cell-cell signaling
GO:0007275 multicellular organism development

Molecular Function

No terms assigned in this category.

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.