Domain

Spumavirus aspartic protease A9 (IPR001641)

Short name: Spumavirus_A9

Domain relationships

None.

Description

Foamy viruses (FV) or spumavirus are single-stranded enveloped retroviruses that have been noted to infect monkeys, cats and humans. In the human virus, the aspartic protease is encoded by the retroviral gag gene [PMID: 2451755], and in monkeys by the pol gene [PMID: 1647358]. At present, the virus has not been proven to cause any particular disease. However, studies have shown Human foamy virus causes neurological disorders in infected mice [PMID: 9549727].

The FV aspartic peptidases belong to MEROPS peptidase family A9 (spumapepsin family, clan AA). It is not clear whether they share a common evolutionary origin with other aspartic proteases.

The FV protease domain consists of seven beta-strands and a helical turn. The beta-strands form a closed barrel-like beta-sheet with the strand order beta1-beta2-beta7-beta3-beta6-beta5-beta1. The strands beta1 and beta7 are arranged in parallel, while all other strands are arranged in an anti-parallel manner [PMID: 18597783].

GO terms

Biological Process

GO:0006508 proteolysis

Molecular Function

GO:0004190 aspartic-type endopeptidase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PROSITE profiles
Pfam
ProDom
PRINTS