Aromatic amino acid beta-eliminating lyase/threonine aldolase (IPR001597)

Short name: ArAA_b-elim_lyase/Thr_aldolase

Overlapping homologous superfamilies

Domain relationships



This domain is found in many tryptophanases (tryptophan indole-lyase, TNase), tyrosine phenol-lyases (TPL) and threonine aldolases. It is involved in the degradation of amino acids. The glycine cleavage system is composed of four proteins: P, T, L and H. In Bacillus subtilis, the P 'protein' is an heterodimer of two subunits. The glycine cleavage system catalyses the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein

GO terms

Biological Process

GO:0006520 cellular amino acid metabolic process

Molecular Function

GO:0016829 lyase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.