Influenza RNA-dependent RNA polymerase subunit PB2 (IPR001591)

Short name: INV_PB2

Overlapping homologous superfamilies


Family relationships



Orthomyxoviridae RNA polymerase with the subunit composition of PB1-PB2-PA is a unique multifunctional enzyme with the activities of both synthesis and cleavage of RNA, and is involved in both transcription and replication of the RNA genome. Transcription is initiated by using capped RNA fragments, which are generated after cleavage of host cell mRNA by the RNA polymerase-associated capped RNA endonuclease [PMID: 8806170]. The PB2 subunit has cap-binding and cap-dependent endonuclease activities [PMID: 10393191]. It appears that two separate sequences, one N-(242-282) and the other C-terminal (538-577) proximal segments of PB2 subunit, constitute the RNA cap-binding site of the Influenza virus RNA polymerase [PMID: 10526235].

GO terms

Biological Process

GO:0039694 viral RNA genome replication

Molecular Function

GO:0003723 RNA binding

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.