Conserved Site

Actinin-type actin-binding domain, conserved site (IPR001589)

Short name: Actinin_actin-bd_CS

Description

Alpha-actinin is a F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures [PMID: 3243032]. The actin-binding domain of alpha-actinin seems to reside in the first 250 residues of the protein. A similar actin-binding domain has been found in the N-terminal region of many different actin-binding proteins [PMID: 2058002, PMID: 1892474], like the beta chain of spectrin (or fodrin), dystrophin, the slime mold gelation factor (or ABP-120), filamin and fimbrin.

This entry represents two conserved sites for the actin-binding domain.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PROSITE patterns
PROSITE patterns