Leukemia inhibitory factor /oncostatin (IPR001581)

Short name: Leukemia_IF/oncostatin

Overlapping homologous superfamilies

Family relationships


On the basis of functional and structural similarities, the small cytokines leukemia inhibitory factor (LIF) and oncostatin (OSM) can be classified into a single family [PMID: 1566332, PMID: 1717982].

It has been said [PMID: 1717982] that LIF and OSM can be included in the IL-6 family of cytokines, but while all these cytokines seem to be structurally related, the sequence similarity is not high enough to allow the use of a single consensus pattern.

GO terms

Biological Process

GO:0006955 immune response

Molecular Function

GO:0005125 cytokine activity

Cellular Component

GO:0005576 extracellular region

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.