Peptidase M8, leishmanolysin (IPR001577)

Short name: Peptidase_M8

Overlapping homologous superfamilies


Family relationships



This group of metallopeptidases belong to the MEROPS peptidase family M8 (leishmanolysin family, clan MA(M)). The protein fold of the peptidase domain for members of this family resembles that of thermolysin, the type example for clan MA.

Leishmanolysin (EC: is an enzyme found in eukaryotes including Leishmania and related parasitic protozoa [PMID: 7674922]. The endopeptidase is the most abundant protein on the cell surface during the promastigote stage of the parasite, and is attached to the membrane by a glycosylphosphatidylinositol anchor [PMID: 7674922]. In the amastigote form, the parasite lives in lysosomes of host macrophages, producing a form of the protease that has an acidic pH optimum [PMID: 7674922]. This differs from most other metalloproteases and may be an adaptation to the environment in which the organism survives [PMID: 7674922].

Homologues are known from human (leishmanolysin-like peptidase or invadolysin [PMID: 19706689] and leishmanolysin-like peptidase 2) and other chordates, but have not been well-characterized


GO terms

Biological Process

GO:0007155 cell adhesion
GO:0006508 proteolysis

Molecular Function

GO:0004222 metalloendopeptidase activity

Cellular Component

GO:0016020 membrane

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.