Cannabinoid receptor type 2 (IPR001551)

Short name: Canbinoid_rcpt_2

Overlapping homologous superfamilies


Family relationships


Cannabinoid receptors are a class of cell membrane receptors that belong to the rhodopsin-like G-protein coupled receptor (GPCR) family [PMID: 12432948, PMID: 18426493, PMID: 19273110]. Typical of G protein-coupled receptors, cannabinoid receptors contain seven transmembrane spanning domains [PMID: 19273110]. Cannabinoid receptors are activated by three major groups of ligands: endocannabinoids, such as N-arachidonoylethanolamine and 2-arachidonoyl glycerol (produced by the mammalian body), plant cannabinoids, such as tetrahydrocannabinol [PMID: 6268916, PMID: 5538858] (produced by the plant Cannabis sativa ) and synthetic cannabinoids, such as HU-210 [PMID: 7565624]. Currently, two known cannabinoid receptor subtypes have been identified, CB1 receptor and CB2 receptor [PMID: 2165569, PMID: 7689702], and are phylogenetically restricted to the chordate branch of the animal kingdom [PMID: 21079038]. The International Union of Basic and Clinical Pharmacology (IUPHAR) has identified five pharmacological targets that could be used to find new cannabinoid receptors or channels [PMID: 21079038], which has resulted in a number of cannabinoid receptors being considered. TRP vanilloid 1 (IPR024863), which is thought to function as an ionotropic cannabinoid receptor [PMID: 21079038], and some deorphanised GPCRs [PMID: 21079038]: GPR18, GPR55, GPR119. However, according to the criteria, no channel, non-CB1/CB2 established receptor or deorphanised receptor can currently be classified fully as a novel cannabinoid receptor [PMID: 21079038].

This entry represents cannabinoid receptor 2 (CB2), which is found primarily in immune tissue [PMID: 7689702], specifically T cells of the immune system, on macrophages and B cells, and in hematopoietic cells [PMID: 21295074, PMID: 7556170]. The CB2 receptor is closely related to CB1 receptor exhibiting 68% homology [PMID: 7689702]. The CB2 receptor has been shown to bind cannabinoid and aminoalkylindole compounds and to signal a response through the inhibition of adenylate cyclase [PMID: 8647116, PMID: 7565624, PMID: 7689702, PMID: 8819477, PMID: 7651369]. The principal endogenous ligand for the CB2 receptor is 2-arachidonoylglycerol (2-AG) [PMID: 9721036, PMID: 7605349, PMID: 22048769]. The primary effect of the CB2 receptor is mainly on the immunological activity of leukocytes [PMID: 10022233], and it has specifically been implicated in a variety of modulatory functions, including immune suppression, induction of apoptosis, and induction of cell migration [PMID: 22048769, PMID: 8937419]. CB2 receptors may have possible therapeutic roles in the treatment of neurodegenerative disorders such as Alzheimer's disease [PMID: 14657172, PMID: 18291574].

GO terms

Biological Process

GO:0007186 G-protein coupled receptor signaling pathway

Molecular Function

GO:0004949 cannabinoid receptor activity

Cellular Component

GO:0016021 integral component of membrane

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.