Domain

Defensin, invertebrate/fungal (IPR001542)

Short name: Defensin_invertebrate/fungal

Domain relationships

Description

Arthropod defensins are a family of insect and scorpion cysteine-rich antibacterial peptides, primarily active against Gram-positive bacteria [PMID: 2911573, PMID: 2358464, PMID: 8471044, PMID: 1761552, PMID: 1425705]. All these peptides range in length from 38 to 51 amino acids. There are six conserved cysteines all involved in intrachain disulphide bonds.

A schematic representation of peptides from the arthropod defensin family is shown below.

        +----------------------------+
        |                   | 
       xxCxxxxxxxxxxxxxxCxxxCxxxxxxxxxCxxxxxCxCxx
                  |  |          | |
                  +---|---------------+ |
                     +-----------------+

'C': conserved cysteine involved in a disulphide bond.
 

Although low level sequence similarities have been reported [PMID: 2911573] between the arthropod defensins and mammalian defensins, the topological arrangement of the disulphide bonds as well as the tertiary structure [PMID: 2401368] are completely different in the two families.

GO terms

Biological Process

GO:0006952 defense response

Molecular Function

No terms assigned in this category.

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PROSITE profiles
Pfam