Mannose-6-phosphate isomerase, type II, C-terminal (IPR001538)

Short name: Man6P_isomerase-2_C

Overlapping homologous superfamilies

Domain relationships



Mannose-6-phosphate isomerase or phosphomannose isomerase (EC: (PMI) is the enzyme that catalyses the interconversion of mannose-6-phosphate and fructose-6-phosphate. In eukaryotes PMI is involved in the synthesis of GDP-mannose, a constituent of N- and O-linked glycans and GPI anchors and in prokaryotes it participates in a variety of pathways, including capsular polysaccharide biosynthesis and D-mannose metabolism. PMI's belong to the cupin superfamily whose functions range from isomerase and epimerase activities involved in the modification of cell wall carbohydrates in bacteria and plants, to non-enzymatic storage proteins in plant seeds, and transcription factors linked to congenital baldness in mammals [PMID: 11165500]. Three classes of PMI have been defined [PMID: 8307007].

The type II phosphomannose isomerases are bifunctional enzymes EC: This entry covers the isomerase region of the protein [PMID: 9507048]. The guanosine diphospho-D-mannose pyrophosphorylase region is described in another InterPro entry (see IPR005836).

GO terms

Biological Process

GO:0005976 polysaccharide metabolic process

Molecular Function

GO:0016779 nucleotidyltransferase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.