Family

Bradykinin receptor B2 (IPR001504)

Short name: Brdyknn_2_rcpt

Family relationships

Description

Bradykinins are a family of short, structurally similar peptides that activate sensory fibres, contract venous smooth muscle, stimulate release of cytokines, induce connective tissue proliferation and mediate endothelium-dependent vasodilation [PMID: 10812256, PMID: 12755382]. Bradykinin antagonists are used in the treatment of inflammation, asthma, mild pain and endotoxic shock.

Bradykinin receptors are members of the seven transmembrane, rhodopsin-like G-protein coupled receptor family and are widespread in peripheral tissues. There are two bradykinins receptor subtypes: B1 and B2. It has also been proposed there could be further subtypes of the bradykinin receptor, including a tracheal B3 receptor but these, as yet have not been confirmed [PMID: 9112069, PMID: 9650825, PMID: 8075864].

This entry represents bradykinin receptor B2, which is the predominant subtype and is ubiquitously and constitutively expressed in healthy tissues [PMID: 15734727]. The B2 receptor mediates slow contraction of various smooth muscles including veins, intestine, uterus, trachea and lung, inducing endothelium-dependent relaxation of arteries and arterioles, and stimulates natriuresis/diuresis in kidney [PMID: 7835885]. Both B1 and B2 receptors are involved in the induction and maintenance of cytokine-induced hyperalgesia, but B2 receptor to a lesser extent [PMID: 8846417]. The B2 receptor couples to Gq and Gi, Gq stimulates phospholipase C to increase intracellular free calcium [PMID: 10653985] and Gi inhibits adenylate cyclase [PMID: 2560387, PMID: 8458876, PMID: 8227332]. Furthermore, the receptor stimulates the mitogen-activated protein kinase pathways [PMID: 7895328]. The B2 receptor also forms a complex with angiotensin converting enzyme (ACE) [PMID: 17077303], and this is thought to play a role in cross-talk between the renin-angiotensin system (RAS) and the kinin-kallikrein system (KKS) [PMID: 11904521].

GO terms

Biological Process

GO:0007186 G-protein coupled receptor signaling pathway
GO:0006950 response to stress
GO:0006939 smooth muscle contraction
GO:0042310 vasoconstriction

Molecular Function

GO:0004947 bradykinin receptor activity

Cellular Component

GO:0016021 integral component of membrane

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PRINTS