Domain

Impact, N-terminal (IPR001498)

Short name: Impact_N

Domain relationships

Description

The Impact protein is a translational regulator that ensures constant high levels of translation under amino acid starvation. It acts by interacting with Gcn1/Gcn1L1, thereby preventing activation of Gcn2 protein kinases (EIF2AK1 to 4) and subsequent down-regulation of protein synthesis. It is evolutionary conserved from eukaryotes to archaea [PMID: 11116084].

This entry represents the N-terminal domain of the Impact proteins.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
Pfam
GENE3D