SOCS box domain (IPR001496)

Short name: SOCS_box

Overlapping homologous superfamilies

Domain relationships


The SOCS box was first identified in SH2-domain-containing proteins of the suppressor of cytokines signalling (SOCS) family [PMID: 9202125] but was later also found in:

  • the WSB (WD-40-repeat-containing proteins with a SOCS box) family,
  • the SSB (SPRY domain-containing proteins with a SOCS box) family,
  • the ASB (ankyrin-repeat-containing proteins with a SOCS box) family,
  • and ras and ras-like GTPases [PMID: 9419338].

The SOCS box found in these proteins is an about 50 amino acid carboxy-terminal domain composed of two blocks of well-conserved residues separated by between 2 and 10 non-conserved residues [PMID: 9419338]. The C-terminal conserved region is an L/P-rich sequence of unknown function, whereas the N-terminal conserved region is a consensus BC box [PMID: 9869640], which binds to the Elongin BC complex [PMID: 9869640, PMID: 10051596]. It has been proposed that this association could couple bound proteins to the ubiquitination or proteasomal compartments [PMID: 10051596].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PROSITE profiles