Domain

SOCS box domain (IPR001496)

Short name: SOCS_box

Domain relationships

None.

Description

The SOCS box was first identified in SH2-domain-containing proteins of the suppressor of cytokines signalling (SOCS) family [PMID: 9202125] but was later also found in:

  • the WSB (WD-40-repeat-containing proteins with a SOCS box) family,
  • the SSB (SPRY domain-containing proteins with a SOCS box) family,
  • the ASB (ankyrin-repeat-containing proteins with a SOCS box) family,
  • and ras and ras-like GTPases [PMID: 9419338].

The SOCS box found in these proteins is an about 50 amino acid carboxy-terminal domain composed of two blocks of well-conserved residues separated by between 2 and 10 non-conserved residues [PMID: 9419338]. The C-terminal conserved region is an L/P-rich sequence of unknown function, whereas the N-terminal conserved region is a consensus BC box [PMID: 9869640], which binds to the Elongin BC complex [PMID: 9869640, PMID: 10051596]. It has been proposed that this association could couple bound proteins to the ubiquitination or proteasomal compartments [PMID: 10051596].

GO terms

Biological Process

GO:0035556 intracellular signal transduction

Molecular Function

No terms assigned in this category.

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
SMART
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Pfam
SMART