Hepatitis C virus non-structural protein NS4b (IPR001490)

Short name: HCV_NS4b

Overlapping homologous superfamilies


Domain relationships



The genome polyprotein contains: caspid protein C, envelope glycoproteins E1 and E2, protein P7, nonstructural protein NS2, protease/helicase NS3, nonstructural proteins NS4A and NS4B (this family), NS5A and NS5B.

The small proteins NS2A, NS2B, NS4A and NS4B are hydrophobic, suggesting a possible membrane-related function [PMID: 9224925]. It is known that NS4B interacts with NS4A and NS3 to form a large replicase complex to direct the viral RNA replication [PMID: 9261364]. NS3 and NS5 may also play a role in the viral RNA replication.

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0003968 RNA-directed 5'-3' RNA polymerase activity
GO:0004197 cysteine-type endopeptidase activity
GO:0017111 nucleoside-triphosphatase activity
GO:0004252 serine-type endopeptidase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.