Heat-stable enterotoxin, STa (IPR001489)

Short name: Heat-stable_enterotox_STa

Overlapping homologous superfamilies


Family relationships



This entry represents a group of heat-stable enterotoxins, such as STa from Escherichia coli, which is the cause of acute diarrhoea in infants and travellers in developing countries. The mature STa protein is a 19-residue peptide containing three disulphide bridges that are functionally important. STa contains an N-terminal signal peptide composed of two domains, Pre and Pro, involved in extracellular toxin release, and a core enterotoxigenic domain [PMID: 15049831]. STa binds to and activates the guanylate cyclise C intestinal receptor, causing an increase in the intracellular levels of cyclic guanosine monophosphate (cGMP) [PMID: 10799798, PMID: 17094787, PMID: 12813912].

GO terms

Biological Process

GO:0009405 pathogenesis

Molecular Function

GO:0090729 toxin activity

Cellular Component

GO:0005615 extracellular space

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.