Domain

Bulb-type lectin domain (IPR001480)

Short name: Bulb-type_lectin_dom

Domain relationships

None.

Description

A bulb lectin super-family (Amaryllidaceae, Orchidaceae and Aliaceae) contains a ~115-residue-long domain whose overall three dimensional fold is very similar to that of [PMID: 9132060, PMID: 7664110]:

  • Dictyostelium discoideum comitin, an actin binding protein
  • Curculigo latifolia curculin, a sweet tasting and taste-modifying protein

This domain generally binds mannose, but in at least one protein, curculin, it is apparently devoid of mannose-binding activity.

Each bulb-type lectin domain consists of three sequential beta-sheet subdomains (I, II, III) that are inter-related by pseudo three-fold symmetry. The three subdomains are flat four-stranded, antiparrallel beta-sheets. Together they form a 12-stranded beta-barrel in which the barrel axis coincides with the pseudo 3-fold axis.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
GENE3D
Pfam
PROSITE profiles
SMART
SUPERFAMILY