Sodium:alanine symporter (IPR001463)

Short name: Na/Ala_symport

Family relationships



Sodium symporters can be divided by sequence and functional similarity into various groups. One such group is the sodium/alanine symporter family, the members of which transport alanine in association with sodium ions.

These transporters are believed to possess 8 transmembrane (TM) helices [PMID: 1447975, PMID: 1400476], forming a channel or pore through the cytoplasmic membrane, the interior face being hydrophilic to allow the passage of alanine molecules and sodium ions [PMID: 1447975]. This family is restricted to the bacteria and archaea, examples are the alanine carrier protein from the Bacillus PS3 (Thermophilic bacterium PS-3); the D-alanine/glycine permease from Pseudoalteromonas haloplanktis (Alteromonas haloplanktis); and the hypothetical protein yaaJ from Escherichia coli.

GO terms

Biological Process

GO:0032328 alanine transport
GO:0006814 sodium ion transport

Molecular Function

GO:0015655 alanine:sodium symporter activity

Cellular Component

GO:0016020 membrane

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PROSITE patterns