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Overview
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Pathways & interactions
5-lipoxygenase-activating protein (IPR001446)
Short name: 5_LipOase_AP
Overlapping homologous superfamilies
Family relationships
- Membrane-associated, eicosanoid/glutathione metabolism (MAPEG) protein (IPR001129)
- 5-lipoxygenase-activating protein (IPR001446)
Description
5-lipoxygenase-activating protein (FLAP) is an integral membrane protein found in cells that produce leukotrienes, the biologically active metabolites of arachidonic acid that have been implicated in a variety of inflammatory responses, including asthma, arthritis and psoriasis [PMID: 2174053].
FLAP appears to activatate 5-lipoxygenase (5LOX) by facilitating its binding to membranes [PMID: 8245774]. It binds arachidonic acid, and may play a role in its transfer to 5LOX. The protein has been shown to bind to MK-886, a compound that blocks leukotriene biosynthesis [PMID: 2174053, PMID: 2300173].
GO terms
Biological Process
GO:0006691 leukotriene metabolic process
Molecular Function
GO:0008047 enzyme activator activity
Cellular Component
GO:0016021 integral component of membrane
Contributing signatures
- PR00488 (5LPOXGNASEAP)