5-lipoxygenase-activating protein (IPR001446)

Short name: 5_LipOase_AP

Overlapping homologous superfamilies

Family relationships


5-lipoxygenase-activating protein (FLAP) is an integral membrane protein found in cells that produce leukotrienes, the biologically active metabolites of arachidonic acid that have been implicated in a variety of inflammatory responses, including asthma, arthritis and psoriasis [PMID: 2174053].

FLAP appears to activatate 5-lipoxygenase (5LOX) by facilitating its binding to membranes [PMID: 8245774]. It binds arachidonic acid, and may play a role in its transfer to 5LOX. The protein has been shown to bind to MK-886, a compound that blocks leukotriene biosynthesis [PMID: 2174053, PMID: 2300173].

GO terms

Biological Process

GO:0006691 leukotriene metabolic process

Molecular Function

GO:0008047 enzyme activator activity

Cellular Component

GO:0016021 integral component of membrane

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.