Tetracycline resistance protein/drug resistance transporter (IPR001411)

Short name: Tet-R_TetB/Drug-R_transptr

Overlapping homologous superfamilies


Family relationships


This entry includes tetracycline resistance proteins Tet(B). Tet(B) is a tetracycline efflux protein that functions as a metal-tetracycline/H+ antiporter [PMID: 11053399]. This is an energy-dependent process that decreases the accumulation of the antibiotic in whole cells. Tet(B) is an integral membrane protein with twelve potential transmembrane domains.

This entry also includes other members of the major facilitator family, including putative multidrug resistance protein MdtD (that like TetB belongs to the TCR/tet subfamily) and drug resistance transporters of the EmrB subfamily.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.