5-Hydroxytryptamine 5A receptor (IPR001397)

Short name: 5HT5A_rcpt

Overlapping homologous superfamilies


Family relationships


5-hydroxytryptamine (5-HT) or serotonin, is a neurotransmitter that it is primarily found in the gastrointestinal (GI) tract, platelets, and in the central nervous system (CNS). It is implicated in a vast array of physiological and pathophysiological pathways. Receptors for 5-HT mediate both excitatory and inhibitory neurotransmission, and modulate the release of many neurotransmitters including glutamate, GABA, dopamine, epinephrine/norepinephrine, and acetylcholine, as well as many hormones, including oxytocin, prolactin, vasopressin and cortisol. In the CNS, 5-HT receptors can influence various neurological processes, such as aggression, anxiety and appetite and, as a, result are the target of a variety of pharmaceutical drugs, including many antidepressants, antipsychotics and anorectics [PMID: 18476671].

The 5-HT receptors are grouped into a number of distinct subtypes, classified according to their antagonist susceptibilities and their affinities for 5-HT. With the exception of the 5-HT3 receptor, which is a ligand-gated ion channel [PMID: 11989819], all 5-HT receptors are members of the rhodopsin-like G protein-coupled receptor family [PMID: 18476671], and they activate an intracellular second messenger cascade to produce their responses.

This entry represents the 5-HT5A receptor, which couples to G proteins and negatively influences cAMP [PMID: 9865521]. It has also been shown to function, in part, through the regulation of intracellular Ca2+ mobilisation [PMID: 12558985]. In the CNS, the 5-HT5A receptor is found in the cerebral cortex, hippocampus, habenula, olfactory bulb and granular layer of the cerebellum [PMID: 7682702, PMID: 7988681, PMID: 10197537]. It may play a role in sleep [PMID: 15921820] and serve as an presynaptic serotonin autoreceptor [PMID: 16846620].

GO terms

Biological Process

GO:0007186 G-protein coupled receptor signaling pathway

Molecular Function

GO:0004993 G-protein coupled serotonin receptor activity

Cellular Component

GO:0016021 integral component of membrane

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.