Domain

Dehydroquinase class I (IPR001381)

Short name: DHquinase_I

Domain relationships

Description

3-dehydroquinate dehydratase (EC:4.2.1.10), or dehydroquinase, catalyzes the conversion of 3-dehydroquinate into 3-dehydroshikimate. It is the third step in the shikimate pathway for the biosynthesis of aromatic amino acids from chorismate. Two classes of dehydroquinases exist, known as types I and II.

The best studied type I enzyme is from Escherichia coli (gene aroD) and related bacteria where it is a homodimeric protein. In fungi, dehydroquinase is part of a multifunctional enzyme which catalyzes five consecutive steps in the shikimate pathway. A histidine [PMID: 1429576] is involved in the catalytic mechanism.

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0003855 3-dehydroquinate dehydratase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
TIGRFAMs
HAMAP
Pfam