3-dehydroquinate dehydratase type I (IPR001381)

Short name: DHquinase_I

Overlapping homologous superfamilies

Family relationships



3-dehydroquinate dehydratase (EC:, or dehydroquinase, catalyzes the conversion of 3-dehydroquinate into 3-dehydroshikimate. It is the third step in the shikimate pathway for the biosynthesis of aromatic amino acids from chorismate. Two classes of dehydroquinases exist, known as types I and II. The best studied type I enzyme is from Escherichia coli (gene aroD) and related bacteria where it is a homodimeric protein. In fungi, dehydroquinase is part of a multifunctional enzyme which catalyses five consecutive steps in the shikimate pathway. A histidine [PMID: 1429576] is involved in the catalytic mechanism.

This entry represents the 3-dehydroquinate dehydratase, type I, either as a monofunctional protein or as a domain of a larger, multifunctional protein.

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0003855 3-dehydroquinate dehydratase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.