Domain

Iron dependent repressor, metal binding and dimerisation domain (IPR001367)

Short name: Fe_dep_repressor

Domain relationships

None.

Description

The diphtheria toxin repressor protein (DTXR) is a member of this group [PMID: 7568230]. In Corynebacterium diphtheriae where it has been studied in some detail this protein acts as an iron-binding repressor of dipheteria toxin gene expression and may serve as a global regulator of gene expression. DTXR comprises an N-terminal DNA-binding domain, an interface domain (which contains two metal-binding sites) and a third, very flexible C-terminal domain. The second domain is responsible for dimerization and metal binding. The N terminus may be involved in iron binding and may associate with the Tox operator. Binding of DTXR to Tox operator requires a divalent metal ion such as cobalt, ferric, manganese and nickel whereas zinc shows weak activation [PMID: 7743135].

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0046983 protein dimerization activity
GO:0046914 transition metal ion binding

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
Pfam