Domain

BRCT domain (IPR001357)

Short name: BRCT_dom

Domain relationships

None.

Description

The BRCT domain (after the C_terminal domain of a breast cancer susceptibility protein) is found predominantly in proteins involved in cell cycle checkpoint functions responsive to DNA damage [PMID: 9034168], for example as found in the breast cancer DNA-repair protein BRCA1. The domain is an approximately 100 amino acid tandem repeat, which appears to act as a phospho-protein binding domain [PMID: 14576433].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
Pfam
GENE3D
Pfam
SUPERFAMILY
SMART
PROSITE profiles