Mandelate racemase/muconate lactonizing enzyme/methylaspartate ammonia-lyase (IPR001354)

Short name: MR/MLE/MAL

Family relationships


This entry includes both the mandelate racemase/muconate lactonizing enzyme family, and the methylaspartate ammonia-lyase family. Both families belong to the enolase superfamily [PMID: 15581566]. Mandelate racemase (EC: and muconate lactonizing enzyme (EC: are two bacterial enzymes involved in aromatic acid catabolism. They catalyse mechanistically distinct reactions yet they are related at the level of their primary, quaternary (homooctamer) and tertiary structures [PMID: 2215699, PMID: 8256284]. Other members of this family include:

  • D-glucarate dehydratase
  • D-xylonate dehydratase [PMID: 19584053]
  • Galactarate dehydratase/L-talarate dehydratase
  • D-arabinonate dehydratase
  • D-galactonate dehydratase [PMID: 324806]
  • D-gluconate dehydratase
  • L-fuconate dehydratase
  • D-tartrate dehydratase
  • L-rhamnonate dehydratase [PMID: 18754693]
  • 2-succinyl-6-hydroxy-2,4-cyclohexa-diene-1-carboxylic acid
  • O-succinylbenzoic acid
  • L-Ala-D/L-Glu epimerase

Methylaspartate ammonia-lyase (EC: is involved in the methylaspartate cycle [PMID: 22005738].

GO terms

Biological Process

GO:0008152 metabolic process

Molecular Function

GO:0003824 catalytic activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.