mRNA capping enzyme, catalytic domain (IPR001339)

Short name: mRNA_cap_enzyme

Overlapping homologous superfamilies


Domain relationships



This entry represents the ATP binding catalytic domain of the mRNA capping enzyme [PMID: 9160746]. The mRNA capping enzyme in yeasts is composed of two separate chains, alpha a mRNA guanyltransferase and beta an RNA 5'-triphosphate. X-ray crystallography reveals a large conformational change during guanyl transfer by mRNA capping enzymes [PMID: 9160746]. Binding of the enzyme to nucleotides is specific to the GMP moiety of GTP. The viral mRNA capping enzyme is a monomer that transfers a GMP cap onto the end of mRNA that terminates with a 5'-diphosphate tail.

GO terms

Biological Process

GO:0006370 7-methylguanosine mRNA capping

Molecular Function

GO:0004484 mRNA guanylyltransferase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.