Family

Peptidyl-tRNA hydrolase (IPR001328)

Short name: Pept_tRNA_hydro

Overlapping homologous superfamilies

Family relationships

None.

Description

Peptidyl-tRNA hydrolase (EC:3.1.1.29) (PTH) is a bacterial enzyme that cleaves peptidyl-tRNA or N-acyl-aminoacyl-tRNA to yield free peptides or N-acyl-amino acids and tRNA. The natural substrate for this enzyme may be peptidyl-tRNA which drop off the ribosome during protein synthesis [PMID: 1833189, PMID: 8635758]. Bacterial PTH has been found to be evolutionary related to a yeast protein [PMID: 8563640].

This group also contains chloroplast RNA splicing 2 (CRS2), which is closely related nuclear-encoded protein required for the splicing of nine group II introns in chloroplasts [PMID: 12881426, PMID: 9303320, PMID: 15078105].

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0004045 aminoacyl-tRNA hydrolase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
Pfam
HAMAP
TIGRFAMs
CDD
PANTHER