Conserved Site

Dihydroorotate dehydrogenase, conserved site (IPR001295)

Short name: Dihydroorotate_DH_CS

Description

Dihydroorotate dehydrogenase (EC:1.3.3.1) (DHOdehase) catalyzes the fourth step in the de novo biosynthesis of pyrimidine, the conversion of dihydroorotate into orotate. DHOdehase is a ubiquitous FAD flavoprotein. In bacteria (gene pyrD), DHOdease is located on the inner side of the cytosolic membrane. In some yeasts, such as in Saccharomyces cerevisiae (gene URA1), it is a cytosolic protein while in other eukaryotes it is found in the mitochondria [PMID: 1409592].

GO terms

Biological Process

GO:0006207 'de novo' pyrimidine nucleobase biosynthetic process
GO:0055114 oxidation-reduction process

Molecular Function

GO:0004152 dihydroorotate dehydrogenase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PROSITE patterns
PROSITE patterns