Family

CCAAT-binding transcription factor, subunit B (IPR001289)

Short name: TF_CBFB

Family relationships

None.

Description

The CCAAT-binding factor (CBFB/NF-YA) is a mammalian transcription factor that binds to a CCAAT motif in the promoters of a wide variety of genes, including type I collagen and albumin [PMID: 2266139]. The factor is a heteromeric complex of A and B subunits, both of which are required for DNA-binding [PMID: 1549471]. The subunits can interact in the absence of DNA-binding, conserved regions in each being important in mediating this interaction.

The B subunit contains a region of similarity with the yeast protein HAP2 [PMID: 2000400]. For the B subunit it has been suggested that the N-terminal portion of the conserved region is involved in subunit interaction and the C-terminal region involved in DNA-binding [PMID: 1569083].

GO terms

Biological Process

GO:0006355 regulation of transcription, DNA-templated

Molecular Function

GO:0003700 sequence-specific DNA binding transcription factor activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PROSITE profiles
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PRINTS
PANTHER
Pfam