Family

Glycoside hydrolase, family 59 (IPR001286)

Short name: Glyco_hydro_59

Family relationships

None.

Description

O-Glycosyl hydrolases (EC:3.2.1.) are a widespread group of enzymes that hydrolyse the glycosidic bond between two or more carbohydrates, or between a carbohydrate and a non-carbohydrate moiety. A classification system for glycosyl hydrolases, based on sequence similarity, has led to the definition of 85 different families [PMID: 7624375, PMID: 8535779]. This classification is available on the CAZy (CArbohydrate-Active EnZymes) web site.

Glycoside hydrolase family 59 GH59 comprises enzymes with only one known activity; galactocerebrosidase (EC:3.2.1.46).

Globoid cell leukodystrophy (Krabbe disease) is a severe, autosomal recessive disorder that results from deficiency of galactocerebrosidase (GALC) activity [PMID: 8661004, PMID: 7601472, PMID: 9434153]. GALC is responsible for the lysosomal catabolism of certain galactolipids, including galactosylceramide and psychosine [PMID: 8661004].

GO terms

Biological Process

GO:0006683 galactosylceramide catabolic process

Molecular Function

GO:0004336 galactosylceramidase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
Pfam
PANTHER
PRINTS